硫酸皮肤素差向异构酶 (DS epimerase) (EC 5.1.3.19) (软骨素-葡萄糖醛酸5-差向异构酶) (T细胞识别的鳞状细胞癌抗原2) (SART-2)
硫酸皮肤素差向异构酶 (DS epimerase) (EC 5.1.3.19) (软骨素-葡萄糖醛酸5-差向异构酶) (T细胞识别的鳞状细胞癌抗原2) (SART-2)
Q9UL01功能描述
将D-葡萄糖醛酸转化为L-艾杜糖醛酸(IdoUA)残基。在糖胺聚糖/粘多糖皮肤素硫酸的生物合成中起重要作用。 {ECO:0000269|PubMed:16505484, ECO:0000269|PubMed:19004833, ECO:0000269|PubMed:7092807, ECO:0000269|Ref.7}.
组织特异性
Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level).
亚细胞定位
Endoplasmic reticulum membrane
关键词