DnaJ同源亚家族B成员6 (HHDJ1) (热休克蛋白J2) (HSJ-2) (MRJ) (MSJ-1)
DnaJ同源亚家族B成员6 (HHDJ1) (热休克蛋白J2) (HSJ-2) (MRJ) (MSJ-1)
O75190功能描述
以剂量依赖和时间依赖的方式对HSP70的ATPase活性产生刺激作用，因此作为HSP70的co-chaperone发挥作用 (PubMed:10954706, PubMed:28233300)。在KRT8/KRT18纤维的组织中起着不可或缺的作用 (PubMed:10954706)。作为包括huntingtin在内的neuronal proteins的内源性molecular chaperone发挥作用 (PubMed:11896048, PubMed:22366786)。抑制含多聚谷氨酰胺、易聚集protein的聚集和毒性 (PubMed:20159555, PubMed:22366786)。还能降低细胞毒性和caspase-3活性 (PubMed:11896048)。 {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:28233300}.; FUNCTION: [Isoform B]: Isoform B而非isoform A抑制huntingtin聚集。 {ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}.
组织特异性
Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
亚细胞定位
Cytoplasm, perinuclear region
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