DMBT1 Q9UGM3

含清道夫受体富半胱氨酸结构域蛋白 DMBT1 (恶性脑肿瘤缺失蛋白1) (糖蛋白340) (Gp-340) (Hensin) (唾液凝集素) (SAG) (肺表面活性物质相关D结合蛋白)

功能描述

可能被认为是脑、肺、食管、胃和结直肠癌的候选抑癌基因。可能在黏膜防御系统、细胞免疫防御和上皮分化中发挥作用。可能作为SFTPD和SPAR的调理素受体，在全身巨噬细胞组织（包括衬于胃肠道的上皮细胞）中发挥作用。可能在肝再生中发挥作用。可能是肝谱系内转运扩增导管（卵圆）细胞命运决定和分化的一个重要因子。早期胚胎发生期间柱状上皮细胞的终末分化所必需的。可能在唾液中作为结合蛋白，用于调节味觉。结合HIV-1包膜蛋白，并已被证明既能抑制又能促进病毒传播。对革兰氏阳性和革兰氏阴性细菌均显示出广泛的钙依赖性结合谱，提示其在防御细菌病原体中发挥作用。结合一系列多硫酸化和多磷酸化配体，这可能解释了其广泛的细菌结合特异性。抑制沙门氏菌（S.enterica）的细胞侵袭。与肌动蛋白细胞骨架相关，并参与受调控胞吐过程中的细胞骨架重塑。以pH依赖性方式与胰酶原相互作用，并可能在胰腺腺泡细胞的受调控分泌途径中作为高尔基体货物受体。 {ECO:0000269|PubMed:10485905, ECO:0000269|PubMed:11007786, ECO:0000269|PubMed:11751412, ECO:0000269|PubMed:16796526, ECO:0000269|PubMed:17548659, ECO:0000269|PubMed:17709527, ECO:0000269|PubMed:19189310, ECO:0000269|PubMed:9288095}。

组织特异性

Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract.

亚细胞定位

Secreted