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DLGAP5 Q15398

盘大相关蛋白5 (DAP-5) (盘大同源蛋白7) (盘大相关蛋白DLG7) (肝细胞癌上调蛋白) (HURP)

蛋白质信息 (UniProt)

盘大相关蛋白5 (DAP-5) (盘大同源蛋白7) (盘大相关蛋白DLG7) (肝细胞癌上调蛋白) (HURP)

Q15398

功能描述

潜在的细胞周期调节因子,可能在癌细胞的致癌过程中发挥作用。受泛素-蛋白酶体途径调节的有丝分裂磷酸蛋白。粘附连接完整性和分化的关键调节因子,可能参与上皮细胞中CDH1介导的粘附和信号传导。 {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}。

组织特异性

Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.

亚细胞定位

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

关键词

3D-structure Alternative splicing Cell cycle Coiled coil Cytoplasm Cytoskeleton Isopeptide bond Nucleus Phosphoprotein Proteomics identification