disks大同源蛋白1 (突触相关蛋白97) (SAP-97) (SAP97) (hDlg)
disks大同源蛋白1 (突触相关蛋白97) (SAP-97) (SAP97) (hDlg)
Q12959功能描述
正常发育所必需的多结构域支架蛋白 (By similarity)。在极化细胞中，将通道、受体和信号分子募集到离散的质膜结构域。通过维持细胞间粘附促进上皮细胞层屏障功能 (By similarity)。可能还在粘附连接组装、信号转导、细胞增殖、突触发生和淋巴细胞活化中发挥作用。通过调节Kv4通道的功能表达来调节心肌细胞的兴奋性。Kv1.5通道的功能调节因子。在海马神经元长时程抑制期间，它将ADAM10募集到质膜 (PubMed:23676497)。 {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}。
组织特异性
Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level) (PubMed:23676497). Widely expressed, with isoforms displaying different expression profiles.
亚细胞定位
Cell membrane
关键词