DKKL1 Q9UK85

Dickkopf样蛋白1 (癌/睾丸抗原34) (CT34) (Soggy-1蛋白) (SGY-1)

功能描述

Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.

组织特异性

More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.

亚细胞定位

Secreted