DIO2 Q92813

II型碘甲腺原氨酸脱碘酶 (EC 1.21.99.4) (5DII) (DIOII) (2型DI) (II型5'-脱碘酶)

功能描述

在甲状腺激素(TH)代谢中发挥关键作用，并通过脱碘作用在TH激活和失活中具有特定作用(PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722)。通过外环脱碘(ORD)催化L-甲状腺素(T4)脱碘生成3,5,3'-三碘甲状腺原氨酸(T3)，3,3',5'-三碘甲状腺原氨酸(rT3)脱碘生成3,3'-二碘甲状腺原氨酸(3,3'-T2)以及3',5'-二碘甲状腺原氨酸(3',5'-T2)脱碘生成3'-单碘甲状腺原氨酸(3'-T1)(PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722, PubMed:18339710)。催化3,3',5'-三碘甲状腺胺和3',5'-二碘甲状腺胺的酚环脱碘(PubMed:18339710)。 {ECO:0000269|PubMed:10403186, ECO:0000269|PubMed:11108274, ECO:0000269|PubMed:12586771, ECO:0000269|PubMed:18339710, ECO:0000269|PubMed:18821722}。

组织特异性

Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:11165050, PubMed:8755651). Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050).

亚细胞定位

Endoplasmic reticulum membrane