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DIAPH2 O60879

透明蛋白同源物2 (透明相关成形蛋白-2) (DRF2)

蛋白质信息 (UniProt)

透明蛋白同源物2 (透明相关成形蛋白-2) (DRF2)

O60879

功能描述

可能参与卵子发生。参与核内体动力学的调节。参与一种新的信号转导通路，在该通路中，亚型3和CSK被RHOD依次激活，通过与肌动蛋白细胞骨架的相互作用来调节早期核内体的运动。 {ECO:0000269|PubMed:12577064}。

组织特异性

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

亚细胞定位

[Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

关键词

Acetylation Alternative splicing Coiled coil Cytoplasm Developmental protein Differentiation Endosome Oogenesis Premature ovarian failure Proteomics identification

外部链接

UniProt: O60879
NCBI Gene