二氢叶酸还原酶 (EC 1.5.1.3)
二氢叶酸还原酶 (EC 1.5.1.3)
P00374功能描述
以依赖NADPH的方式催化7,8-二氢叶酸(DHF)还原为5,6,7,8-四氢叶酸 (PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595)。叶酸代谢中的关键酶。参与核和线粒体从头胸苷酸生物合成途径 (PubMed:21876188, PubMed:22235121)。催化从头甘氨酸和嘌呤合成以及DNA前体合成所必需的反应。结合其自身mRNA及DHFR2的mRNA。 {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:17569517, ECO:0000269|PubMed:19196009, ECO:0000269|PubMed:19478082, ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:22235121, ECO:0000269|PubMed:9719595}。
组织特异性
Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.
亚细胞定位
Mitochondrion
关键词