Delta(24)-固醇还原酶 (EC 1.3.1.72) (24-脱氢胆固醇还原酶) (3-β-羟基固醇Delta-24-还原酶) (Diminuto/dwarf1同源蛋白) (Seladin-1)
Delta(24)-固醇还原酶 (EC 1.3.1.72) (24-脱氢胆固醇还原酶) (3-β-羟基固醇Delta-24-还原酶) (Diminuto/dwarf1同源蛋白) (Seladin-1)
Q15392功能描述
催化胆固醇生物合成过程中固醇中间体delta-24双键的还原 (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936)。除了其胆固醇合成活性外，还可以通过在氧化应激诱导的细胞凋亡过程中降低caspase 3活性来保护细胞免受氧化应激损伤 (PubMed:11007892, PubMed:22010141)。还能防止amyloid-beta肽诱导的细胞凋亡 (PubMed:11007892)。 {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:21671375, ECO:0000269|PubMed:22010141, ECO:0000269|PubMed:22178193, ECO:0000269|PubMed:25637936}。
组织特异性
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
亚细胞定位
Endoplasmic reticulum membrane
关键词