DENND2D Q9H6A0

含DENN结构域蛋白2D

功能描述

鸟嘌呤核苷酸交换因子 (GEF)，可能激活 RAB9A 和 RAB9B。促进 GDP 交换为 GTP，将无活性的 GDP 结合型 Rab 蛋白转化为其有活性的 GTP 结合形式。 {ECO:0000269|PubMed:20937701}。

组织特异性

In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.

亚细胞定位

Cytoplasm