DEFB4A O15263

防御素β4A (β-防御素2) (BD-2) (hBD-2) (防御素，β2) (皮肤抗菌肽1) (SAP1)

功能描述

对革兰氏阴性菌和革兰氏阳性菌表现出抗菌活性，对革兰氏阴性菌的活性最高 (PubMed:10837369, PubMed:9202117)。对铜绿假单胞菌 (P.aruginosa) 的抗菌活性似乎对盐敏感，在高于 25 mM 的高盐浓度下活性降低 (PubMed:10837369)。还对酵母白色念珠菌 (C.albicans) 表现出抗菌活性 (PubMed:10837369, PubMed:30050988, PubMed:9202117)。通过靶向质膜脂质磷脂酰肌醇 4,5-二磷酸 (PIP2) 破坏白色念珠菌 (C.albicans) 细胞膜的通透性，从而导致细胞破碎和细胞死亡 (PubMed:30050988)。作为 C-C 趋化因子受体 CCR6 的配体 (PubMed:10521347, PubMed:20068036)。与 CCR6 结合并诱导表达 CCR6 的细胞（如未成熟树突状细胞和记忆 T 细胞）的趋化活性 (PubMed:10521347, PubMed:20068036)。 {ECO:0000269|PubMed:10521347, ECO:0000269|PubMed:10837369, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:30050988, ECO:0000269|PubMed:9202117}。

组织特异性

Expressed in lung epithelial cells (at protein level) (PubMed:10837369). Expressed in foreskin, lung and trachea (PubMed:9202117). Lower expression in kidney, uterus and salivary gland tissue (PubMed:9202117). Expressed in epithelial cells of the respiratory tract, with higher expression in distal parenchyma of the lung, trachea, and tonsils, and lower expression in pharynx and adenoid, and low expression in tongue and larynx (PubMed:10837369, PubMed:9831658).

亚细胞定位

Secreted