DEAF1 O75398

表皮自调节因子1同源蛋白 (核DEAF-1相关转录调节因子) (NUDR) (Suppressin) (含MYND结构域锌指蛋白5)

功能描述

转录因子，结合于其自身启动子及HNRPA2B1基因启动子中存在的含有多个5'-TTC[CG]G-3'拷贝的序列。下调这些基因的转录。结合视黄酸反应元件(RARE) 5'-AGGGTTCACCGAAAGTTCA-3'。不依赖启动子结合激活脑啡肽原基因，可能通过protein-protein相互作用。分泌后，作为细胞增殖的抑制剂，通过将细胞阻滞在G0或G1期。神经管闭合和骨骼模式形成所必需。调节乳腺上皮细胞增殖和侧支分支。控制胰腺淋巴结中外周组织抗原的表达。Isoform 1比isoform 4显示更强的转录活性。Isoform 4可能通过与isoform 1相互作用并将其滞留在细胞质中，从而抑制isoform 1的转录活性。EIF4G3的转录激活因子。 {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:0000269|PubMed:11705868, ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}.

组织特异性

Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and adult brain.

亚细胞定位

[Isoform 1]: Nucleus. Cytoplasm. Note=Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted. Note=Secreted in some cell types.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Note=Secreted in some cell types.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced.