DDO Q99489

D-天冬氨酸氧化酶 (DASOX) (DASPO) (DDO) (EC 1.4.3.1)

功能描述

选择性地催化酸性氨基酸的氧化脱氨作用 (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMed:9163533)。抑制大脑中D-天冬氨酸的水平，该氨基酸可作为谷氨酸受体的激动剂 (PubMed:28560262)。保护机体免受D-氨基酸的毒性 (By similarity)。可能也在肠道中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:D3ZDM7, ECO:0000250|UniProtKB:Q922Z0, ECO:0000269|PubMed:1991137, ECO:0000269|PubMed:20603179, ECO:0000269|PubMed:23391306, ECO:0000269|PubMed:25747990, ECO:0000269|PubMed:28393897, ECO:0000269|PubMed:28560262, ECO:0000269|PubMed:28629864, ECO:0000269|PubMed:29292239, ECO:0000269|PubMed:31914658, ECO:0000269|PubMed:32553892, ECO:0000269|PubMed:9163533}。

组织特异性

Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level) (PubMed:12209855, PubMed:1991137). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level) (PubMed:12209855, PubMed:28560262). Expression is increased in the prefrontal cortex of schizophrenic patients (PubMed:25689573). Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease (PubMed:30822420).

亚细胞定位

Peroxisome matrix