DCUN1D3 Q8IWE4

DCN1样蛋白3 (DCNL3) (含DCUN1结构域蛋白3) (Cullin Neddylation缺陷蛋白1样蛋白3) (鳞状细胞癌相关癌基因3)

功能描述

通过将NEDD8从N端乙酰化的NEDD8结合E2s酶转移至不同的cullin C末端结构域-RBX复合物，促进所有cullins的neddylation，并可能通过在UV损伤后调节SCF泛素E3连接酶复合物在细胞周期进程中发挥作用 (PubMed:18823379, PubMed:19617556, PubMed:23201271, PubMed:27542266)。在细胞膜上，可以促进也可以抑制cullins的neddylation (PubMed:19617556, PubMed:25349211, PubMed:26906416)。 {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:27542266}。

组织特异性

Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556).

亚细胞定位

Cell membrane