DCANP1 Q8TF63

树突状细胞核蛋白1 (树突状细胞核蛋白-1) (树突状细胞相关核蛋白)

功能描述

结合并反式激活促肾上腺皮质激素释放激素 (CRH) 启动子。 {ECO:0000269|PubMed:20693543}。

组织特异性

Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells.

亚细胞定位

Nucleus