CYSLTR1 Q9Y271

半胱氨酰白三烯受体1 (CysLTR1) (半胱氨酰白三烯D4受体) (LTD4受体) (G蛋白偶联受体HG55) (HMTMF81)

功能描述

半胱氨酰白三烯受体，介导哮喘和非哮喘个体的支气管收缩。LTD4的刺激导致平滑肌收缩和增殖、水肿、嗜酸性粒细胞迁移以及肺部粘液层损伤。该反应通过G蛋白介导，该蛋白激活磷脂酰肌醇-钙第二信使系统。对白三烯的亲和力排序为LTD4 >> LTE4 = LTC4 >> LTB4。

组织特异性

Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

亚细胞定位

Cell membrane; Multi-pass membrane protein.