CYP4X1 Q8N118

细胞色素P450 4X1 (EC 1.14.14.-) (CYPIVX1)

功能描述

一种细胞色素P450单加氧酶，选择性催化anandamide的花生四烯酰基部分最后一个双键的环氧化作用，可能调节内源性大麻素信号传导。对各种脂肪酸、类固醇和前列腺素没有羟化酶活性。在机制上，利用分子氧将一个氧原子插入底物，并将第二个氧原子还原成水分子，所需的两个电子由NADPH通过细胞色素P450还原酶（CPR; NADPH-铁血红素蛋白还原酶）提供。 {ECO:0000269|PubMed:18549450}。

组织特异性

Expressed in brain, heart, kidney and skin and, at lower levels, in skeletal muscle and liver (PubMed:16478468, PubMed:18549450). In the brain, high levels are detected in amygdala and lower levels in globus pallidus and cerebellum (PubMed:18549450). In the heart, very high levels in aorta, but very low levels in other heart regions (PubMed:16478468, PubMed:18549450). Also expressed in breast, prostate and colon (PubMed:18549450).

亚细胞定位

Endoplasmic reticulum membrane