细胞色素P450 2A13 (EC 1.14.14.1) (CYPIIA13)
细胞色素P450 2A13 (EC 1.14.14.1) (CYPIIA13)
Q16696功能描述
表现出香豆素7-羟化酶活性。在六甲基磷酰胺、N,N-二甲基苯胺、2'-甲氧基苯乙酮、N-亚硝基甲基苯胺以及烟草特异性致癌物4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁酮的代谢活化中具有活性。具有非那西丁O-脱乙基活性。 {ECO:0000269|PubMed:18779312}。
组织特异性
Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.
亚细胞定位
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
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