返回首页

CXCL11 O14625

C-X-C基序趋化因子11 (Beta-R1) (H174) (干扰素γ诱导蛋白9) (IP-9) (干扰素诱导T细胞α趋化因子) (I-TAC) (小诱导细胞因子B11)

蛋白质信息 (UniProt)

C-X-C基序趋化因子11 (Beta-R1) (H174) (干扰素γ诱导蛋白9) (IP-9) (干扰素诱导T细胞α趋化因子) (I-TAC) (小诱导细胞因子B11)

O14625

功能描述

对白细胞介素激活的T细胞具有趋化作用,但对未受刺激的T细胞、中性粒细胞或单核细胞无趋化作用。诱导活化T细胞内的钙释放。与CXCR3结合。可能在涉及T细胞募集的中枢神经系统(CNS)疾病中发挥重要作用。可能在皮肤免疫应答中发挥作用。

组织特异性

High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

亚细胞定位

Secreted.

关键词

3D-structure Chemotaxis Citrullination Cytokine Direct protein sequencing Disulfide bond Inflammatory response Proteomics identification Reference proteome Secreted