柯萨奇病毒和腺病毒受体 (CAR) (hCAR) (CVB3结合蛋白) (柯萨奇病毒B-腺病毒受体) (HCVADR)
柯萨奇病毒和腺病毒受体 (CAR) (hCAR) (CVB3结合蛋白) (柯萨奇病毒B-腺病毒受体) (HCVADR)
P78310功能描述
上皮顶端连接复合物的组分，可能作为同嗜性细胞粘附分子发挥作用，对于紧密连接的完整性至关重要。还通过与其JAML（白细胞质膜上的跨膜蛋白）的粘附相互作用参与白细胞的跨上皮迁移。这两种受体之间的相互作用还介导了gamma-delta T细胞的激活，gamma-delta T细胞是驻留在上皮组织中的T细胞亚群，参与组织稳态和修复。在上皮CXADR结合后，JAML通过PI3-kinase和MAP激酶在gamma-delta T细胞中诱导下游细胞信号事件。这导致T细胞增殖并产生细胞因子和生长因子，进而刺激上皮组织修复。 {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) 作为C型腺病毒的受体。 {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) 作为柯萨奇病毒B1至B6的受体。 {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.
组织特异性
Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
亚细胞定位
[Isoform 1]: Cell membrane
关键词