酪蛋白激酶I ε同工型 (CKI-epsilon) (CKIe) (EC 2.7.11.1)
酪蛋白激酶I ε同工型 (CKI-epsilon) (CKIe) (EC 2.7.11.1)
P49674功能描述
酪蛋白激酶的操作性定义在于其优先利用酸性蛋白（如酪蛋白）作为底物 (Probable)。参与Wnt信号通路 (PubMed:12556519, PubMed:23413191)。磷酸化DVL1 (PubMed:12556519)。磷酸化DVL2 (PubMed:23413191)。磷酸化NEDD9/HEF1 (By similarity)。生物钟的核心组分 (PubMed:16790549)。与PP1相平衡，通过调节PER1和PER2磷酸化的速度和节律性，决定生物钟的周期长度 (PubMed:15917222, PubMed:16790549)。控制PER1和PER2的核转运和降解 (By similarity)。抑制细胞因子诱导的粒细胞分化 (PubMed:15070676)。 {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}。
组织特异性
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
亚细胞定位
Cytoplasm
关键词