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CSF3R Q99062

粒细胞集落刺激因子受体 (G-CSF受体) (G-CSF-R) (CD抗原CD114)

蛋白质信息 (UniProt)

粒细胞集落刺激因子受体 (G-CSF受体) (G-CSF-R) (CD抗原CD114)

Q99062

功能描述

粒细胞集落刺激因子 (CSF3) 的受体,对粒细胞成熟至关重要。在中性粒细胞谱系细胞的增殖、分化和存活中发挥关键作用。此外,它可能在细胞表面的某些粘附或识别事件中发挥作用。 {ECO:0000269|PubMed:7514305}。

组织特异性

One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.

亚细胞定位

[Isoform 2]: Secreted

关键词

3D-structure Alternative splicing Cell adhesion Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Membrane