CREB调节的转录共激活因子2 (cAMP反应元件结合蛋白调节的转导因子2) (TORC-2) (CREB蛋白转导因子2)
CREB调节的转录共激活因子2 (cAMP反应元件结合蛋白调节的转导因子2) (TORC-2) (CREB蛋白转导因子2)
Q53ET0功能描述
CREB1的转录共激活因子，通过共有和变异cAMP反应元件(CRE)位点激活转录。作为SIK/TORC信号通路中的共激活因子，在去磷酸化时具有活性，且不依赖于CREB1 'Ser-133'磷酸化。增强CREB1与TAF4的相互作用。作为LKB1/AMPK/TORC2信号通路的组分调节糖异生。调节特定基因的表达，如类固醇生成基因StAR。是PPARGC1A的强效共激活因子，也是肌细胞中线粒体生物发生的诱导因子。也是TAX激活人T细胞白血病病毒1型(HTLV-1)长末端重复序列(LTR)的共激活因子。 {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}。
组织特异性
Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
亚细胞定位
Cytoplasm
关键词