CRNN Q9UBG3

Cornulin (53 kDa 推定钙结合蛋白) (53 kDa 鳞状上皮诱导应激蛋白) (58 kDa 热休克蛋白) (鳞状上皮热休克蛋白 53) (肿瘤相关蛋白)

功能描述

促进细胞增殖、G1/S细胞周期进程，并诱导细胞周期调节因子CCND1的表达 (PubMed:30009832)。通过激活NFKB1和PI3K/AKT信号通路，调节由促炎细胞因子反应诱导的增殖 (PubMed:30009832)。 {ECO:0000269|PubMed:30009832}。

组织特异性

Expressed in the basal skin layer (at protein level) (PubMed:30009832). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).

亚细胞定位

Cytoplasm