CREBZF Q9NS37

CREB/ATF bZIP转录因子 (宿主细胞因子结合转录因子Zhangfei) (HCF结合转录因子Zhangfei)

功能描述

与HCFC1结合时强烈激活转录。以依赖HCFC1的方式抑制病毒感染细胞中HSV蛋白的表达。也抑制CREB3依赖HCFC1的转录激活并减少细胞中CREB3的量。能够在表达CREBZF的细胞中下调某些细胞基因的表达。 {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}。

组织特异性

In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.

亚细胞定位

Nucleus