CRB3 Q9BUF7

Crumbs同源蛋白3

功能描述

参与哺乳动物上皮细胞极性的建立 (PubMed:12771187, PubMed:14718572, PubMed:23439680)。调节紧密连接的形态发生 (PubMed:12771187, PubMed:14718572)。参与促进转录共激活因子YAP1和WWTR1/TAZ的磷酸化及胞质滞留，从而抑制TGFB1依赖性靶基因（如CCN2/CTGF、SERPINE1/PAI1、SNAI1/SNAIL1和SMAD7）的转录 (By similarity)。 {ECO:0000250|UniProtKB:Q8QZT4, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572, ECO:0000269|PubMed:23439680}。

组织特异性

Preferentially expressed in epithelial tissues (PubMed:14718572). Expressed at high levels in lung, kidney, and colon (PubMed:12527193, PubMed:14718572). Expressed at high levels in retina, colon and mammary glands (PubMed:12527193). Moderately expressed in liver, spleen, pancreas and prostate (PubMed:12527193). Moderately to weakly expressed in the placenta (PubMed:12527193, PubMed:14718572). Weakly expressed in skeletal muscle and small intestine (PubMed:14718572).

亚细胞定位

Apical cell membrane