CRADD P78560

含死亡结构域蛋白CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)

蛋白质信息 (UniProt)

含死亡结构域蛋白CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)

P78560

功能描述

适配蛋白，与PIDD1和caspase CASP2结合形成PIDDosome，该复合物激活CASP2并引发细胞凋亡 (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836)。亦通过其与RIPK1和TRADD的相互作用将CASP2募集至TNFR-1信号复合物，并可能在肿瘤坏死因子介导的信号通路中发挥作用 (PubMed:8985253)。 {ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16652156, ECO:0000269|PubMed:17159900, ECO:0000269|PubMed:17289572, ECO:0000269|PubMed:8985253, ECO:0000269|PubMed:9044836}。

组织特异性

Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Apoptosis Cytoplasm Disease variant Intellectual disability Lissencephaly Nucleus Proteomics identification Reference proteome

外部链接

UniProt: P78560

NCBI Gene

GeneCards