CPLX2 Q6PUV4

Complexin-2 (Complexin II) (CPX II) (Synaphin-1)

功能描述

负调控有丝分裂后神经元中活性区突触囊泡聚类在突触前膜的形成。正调控多种细胞质囊泡（如突触囊泡和其他分泌囊泡）胞吐作用的晚期步骤。也参与肥大细胞胞吐作用（通过相似性）。{ECO:0000250|UniProtKB:P84086, ECO:0000250|UniProtKB:P84088}。

组织特异性

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.

亚细胞定位

Cytoplasm, cytosol