COMMD5 Q9GZQ3

含COMM结构域蛋白5 (高血压相关钙调节基因蛋白) (HCaRG)

功能描述

Commander复合物中的支架蛋白，对于跨膜货物的内体循环至关重要；commander复合物由CCC亚复合物和retriever亚复合物组成 (PubMed:37172566, PubMed:38459129)。可能调节cullin-RING E3泛素连接酶 (CRL) 复合物的活性 (PubMed:21778237)。负向调节细胞增殖 (By similarity)。可能通过p53/TP53非依赖性信号通路反式激活p21/CDKN1A，从而负向调节细胞周期G2/M期转换 (By similarity)。参与肾近端小管形态发生 (By similarity)。下调NF-kappa-B的激活 (PubMed:15799966)。 {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.

组织特异性

Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.

亚细胞定位

Cytoplasm