COLEC12 Q5KU26

Collectin-12 (胎盘Collectin蛋白1) (CL-P1) (hCL-P1) (抚育细胞清道夫受体2) (A类清道夫受体成员4) (含C型凝集素的清道夫受体)

功能描述

清道夫受体，表现出多种与宿主防御相关的功能。促进革兰氏阳性菌、革兰氏阴性菌和酵母的结合与吞噬。介导血管内皮细胞对氧化修饰的低密度脂蛋白(oxLDL)的识别、内化和降解。以钙依赖性方式结合多种碳水化合物，包括Gal型配体、D-半乳糖、L-岩藻糖和D-岩藻糖、GalNAc、T和Tn抗原，并在类护理细胞中特异性内化GalNAc。也结合唾液酸路易斯X或一种三糖以及去唾液酸血清类粘蛋白(ASOR)。可能在阿尔茨海默病中淀粉样蛋白-β的清除中发挥作用。 {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}。

组织特异性

Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.

亚细胞定位

Membrane