COL8A1 P27658

VIII型胶原α1链 (内皮胶原) [剪切为：Vastatin]

功能描述

内皮下的大分子成分。角膜内皮细胞Descemet膜（基底膜）的主要成分。也是血管内皮的成分之一。为血管平滑肌细胞的迁移和增殖所必需，因此在维持血管壁完整性和结构方面具有潜在作用，特别是在动脉粥样硬化形成过程中。 {ECO:0000269|PubMed:11708810}.; FUNCTION: Vastatin，包含NC1结构域的C末端片段，抑制主动脉内皮细胞增殖并导致细胞凋亡。 {ECO:0000269|PubMed:11708810}.

组织特异性

Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.

亚细胞定位

Secreted, extracellular space, extracellular matrix, basement membrane.