胞质非特异性二肽酶 (EC 3.4.13.18) (CNDP二肽酶2) (谷氨酸羧肽酶样蛋白1) (肽酶A) (苏氨酰二肽酶)
胞质非特异性二肽酶 (EC 3.4.13.18) (CNDP二肽酶2) (谷氨酸羧肽酶样蛋白1) (肽酶A) (苏氨酰二肽酶)
Q96KP4功能描述
催化二肽中的肽键水解，对苏氨酰二肽表现出非冗余活性 (By similarity)。以组织特异性方式介导苏氨酰二肽分解代谢 (By similarity)。对半胱氨酰甘氨酸（谷胱甘肽代谢的中间代谢物）具有高二肽酶活性 (PubMed:12473676, PubMed:19346245)。代谢N-乳酰氨基酸，既通过水解生成乳酸和氨基酸，也通过逆向蛋白水解作用形成它们 (PubMed:25964343)。在细胞周期停滞和凋亡的调节中发挥作用 (PubMed:17121880, PubMed:24395568)。 {ECO:0000250|UniProtKB:Q9D1A2, ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568, ECO:0000269|PubMed:25964343}。
组织特异性
[Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level) (PubMed:24395568).
亚细胞定位
Cytoplasm
关键词