CMKLR1 Q99788

Chemerin样受体1 (趋化因子样受体1) (G蛋白偶联受体ChemR23) (G蛋白偶联受体DEZ)

功能描述

趋化剂脂肪因子chemerin/RARRES2和ω-3脂肪酸衍生分子resolvin E1的受体。与RARRES2相互作用启动G蛋白G(i)/G(o)和β-arrestin通路的激活，通过细胞内钙动员、MAP激酶MAPK1/MAPK3 (ERK1/2)、TYRO3、MAPK14/P38MAPK和PI3K的磷酸化等第二信使通路诱导细胞反应，导致多功能效应，如免疫反应减弱、脂肪生成和血管生成增强 (PubMed:27716822)。Resolvin E1通过减少MAPK1/3 (ERK1/2)和NF-kappa-B的活化来下调巨噬细胞中细胞因子的产生。正向调节脂肪生成和脂肪细胞代谢。 {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:27716822}.; FUNCTION: (Microbial infection) 作为几种SIV毒株 (SIVMAC316, SIVMAC239, SIVMACL7E-FR和SIVSM62A) 以及一种主要HIV-1毒株 (92UG024-2) 的共受体。 {ECO:0000269|PubMed:9603476}.

组织特异性

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.

亚细胞定位

Cell membrane