CLEC12A Q5QGZ9

C型凝集素结构域家族12成员A (C型凝集素样分子1) (CLL-1) (树突状细胞相关凝集素2) (DCAL-2) (杀伤细胞C型凝集素样受体L1) (hKLRL1) (髓系抑制性C型凝集素样受体) (MICL) (CD抗原CD371)

功能描述

髓系抑制性C型凝集素受体，作为髓系细胞活化的负调控因子 (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217)。髓系细胞抑制作用对于限制促炎通路和防止过度炎症是必需的 (By similarity)。特异性识别并结合多种结构，例如中性粒细胞胞外诱捕网 (NETs) 或单钠尿酸盐晶体 (PubMed:38367667, PubMed:38386511, PubMed:39143217)。也作为病原体相关分子的模式识别受体，例如疟原虫血红素或分枝杆菌霉菌酸 (PubMed:31269448, PubMed:36542980)。配体结合诱导其ITIM基序磷酸化，随后招募酪氨酸蛋白磷酸酶PTPN6和PTPN11，它们拮抗酪氨酸蛋白激酶SYK，从而阻止髓系细胞活化 (PubMed:14739280, PubMed:16239426, PubMed:34234773)。在中性粒细胞中作为NETs的模式识别受体：特异性识别NETs中的DNA，导致抑制中性粒细胞活化并限制进一步的NET形成 (PubMed:39143217)。这种调控对于控制关键的中性粒细胞反应和限制NET介导的炎症状况至关重要 (By similarity)。也通过作为单钠尿酸盐晶体的受体识别死亡细胞，导致下调中性粒细胞活化 (PubMed:38367667, PubMed:38386511)。与单钠尿酸盐晶体结合也促进I型干扰素反应 (By similarity)。作为自然杀伤 (NK) 细胞细胞毒性的抑制剂 (PubMed:15238421)。也以依赖IL10的方式作为树突状细胞成熟的抑制剂 (PubMed:16239426)。 {ECO:0000250|UniProtKB:Q504P2, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15238421, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:31269448, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:36542980, ECO:0000269|PubMed:38367667, ECO:0000269|PubMed:38386511, ECO:0000269|PubMed:39143217}。

组织特异性

Preferentially expressed in lymphoid tissues and immune cells, including natural killer (NK) cells, T-cells, dendritic cells and monocytes or macrophages (PubMed:14739280, PubMed:15238421, PubMed:15548716, PubMed:16239426, PubMed:16838277). Detected in spleen macrophage-rich red pulp and in lymph node (at protein level) (PubMed:16838277). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages (PubMed:16838277).

亚细胞定位

Cell membrane