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CLDN17 P56750

克劳丁-17

蛋白质信息 (UniProt)

克劳丁-17

P56750

功能描述

成孔型紧密连接蛋白,对阴离子(包括氯离子和碳酸氢根离子)以及直径小于9埃的溶质具有选择性。在肾脏近曲小管中,可能参与滤过阴离子的旁细胞重吸收。不影响水通透性。 {ECO:0000269|PubMed:22402829, ECO:0000269|PubMed:26194246}。

组织特异性

In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).

亚细胞定位

Cell junction, tight junction

关键词

Cell junction Cell membrane Chloride Chloride channel Ion channel Ion transport Membrane Proteomics identification Reference proteome Tight junction