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CLDN15 P56746

密封蛋白-15

蛋白质信息 (UniProt)

密封蛋白-15

P56746

功能描述

形成旁细胞通道:在紧密连接链中聚合,形成贯穿链的阳离子和水选择性通道,在称为旁细胞紧密连接通透性的过程中传递上皮通透性 (PubMed:12055082, PubMed:13129853, PubMed:31188544, PubMed:35650657, PubMed:36008380)。在肠上皮中,允许钠和水从腹膜侧流向肠腔,以调节营养吸收和肠道形态发生 (By similarity)。 {ECO:0000250|UniProtKB:Q9Z0S5, ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853, ECO:0000269|PubMed:31188544, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}。

组织特异性

Detected in colon (at protein level).

亚细胞定位

Cell junction, tight junction

关键词

Cell junction Cell membrane Disulfide bond Ion transport Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Reference proteome