半乳糖凝集素-10 (Gal-10) (夏科-莱登晶体蛋白) (CLC) (嗜酸性粒细胞溶血磷脂酶) (溶血卵磷脂酰基水解酶)
半乳糖凝集素-10 (Gal-10) (夏科-莱登晶体蛋白) (CLC) (嗜酸性粒细胞溶血磷脂酶) (溶血卵磷脂酰基水解酶)
Q05315功能描述
通过识别细胞表面聚糖调节免疫反应。对于CD25阳性调节性T细胞(Treg)的无反应性和抑制功能至关重要。 {ECO:0000269|PubMed:17502455}。
组织特异性
Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).
亚细胞定位
Cytoplasm, cytosol
关键词