CKAP2 Q8WWK9

细胞骨架相关蛋白 2 (CTCL肿瘤抗原se20-10) (肿瘤和微管相关蛋白)

功能描述

具有微管稳定特性。参与以p53/TP53依赖性方式调节非整倍性、细胞周期和细胞死亡（根据相似性）。{ECO:0000250}。

组织特异性

Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

亚细胞定位

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.