碳水化合物磺基转移酶8 (EC 2.8.2.-) (GalNAc-4-O-磺基转移酶1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-乙酰半乳糖胺-4-O-磺基转移酶1)
碳水化合物磺基转移酶8 (EC 2.8.2.-) (GalNAc-4-O-磺基转移酶1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-乙酰半乳糖胺-4-O-磺基转移酶1)
Q9H2A9功能描述
催化硫酸基团转移至N-聚糖和O-聚糖中非还原性N-乙酰半乳糖胺（GalNAc）残基的4位。在连接于N-连接和核心2分支O-连接寡糖的GalNAcbeta1->4GlcNAcbeta1->R结构中，将硫酸基团转移至GalNAc的4位。通过介导糖蛋白激素黄体生成素和促甲状腺激素碳水化合物结构的硫酸化，参与这两种激素的生物合成（PubMed:10988300, PubMed:11001942, PubMed:11445554, PubMed:28204496）。对硫酸软骨素和硫酸皮肤素无活性（PubMed:10988300, PubMed:11001942, PubMed:11445554）。 {ECO:0000269|PubMed:10988300, ECO:0000269|PubMed:11001942, ECO:0000269|PubMed:11445554, ECO:0000269|PubMed:28204496}。
组织特异性
Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea.
亚细胞定位
Golgi apparatus membrane
关键词