CHRDL2 Q6WN34

Chordin样蛋白2 (乳腺肿瘤新因子1) (BNF-1) (Chordin相关蛋白2)

功能描述

可能通过阻断BMPs与其受体的相互作用来抑制BMPs活性。对未成熟间充质细胞的软骨形成/再生具有负调控作用，通过阻止或降低基质积累的速率（By similarity）。参与肿瘤血管生成。可能在成肌细胞和成骨细胞的分化及成熟过程中发挥作用。 {ECO:0000250, ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:15094188}。

组织特异性

Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.

亚细胞定位

[Isoform 1]: Secreted