CHPT1 Q8WUD6

胆碱磷酸转移酶1 (hCPT1) (EC 2.7.8.2) (AAPT1样蛋白) (二酰甘油胆碱磷酸转移酶1)

功能描述

催化de novo磷脂酰胆碱(PC)合成的最后一步，即将胆碱磷酸从CDP-胆碱转移至二酰甘油(DAG)的游离羟基，生成PC。因此在囊泡膜的形成和维持中发挥核心作用。 {ECO:0000269|PubMed:10893425}。

组织特异性

Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines.

亚细胞定位

Golgi apparatus membrane