CFAP52 Q8N1V2

纤毛和鞭毛相关蛋白52 (WD重复序列包含蛋白16) (肝癌中上调的WD40重复蛋白)

蛋白质信息 (UniProt)

纤毛和鞭毛相关蛋白52 (WD重复序列包含蛋白16) (肝癌中上调的WD40重复蛋白)

Q8N1V2

功能描述

纤毛轴丝中动力蛋白装饰的双微管（DMTs）的微管内蛋白（MIP）组分（PubMed:36191189）。对于正常的纤毛和鞭毛摆动至关重要。可能与CFAP45和轴丝动力蛋白亚基DNAH11协同作用（PubMed:33139725）。可能在细胞生长和/或存活中发挥作用（PubMed:15967112）。 {ECO:0000250|UniProtKB:E1BKF9, ECO:0000269|PubMed:15967112, ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:36191189}。

组织特异性

Expressed in respiratory cells and sperm (at protein level) (PubMed:33139725, PubMed:36191189). Highly expressed in testis (PubMed:15967112). Up-regulated in hepatocellular carcinoma (HCC) (PubMed:15967112).

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Cell projection Cilium Cytoplasm Cytoskeleton Disease variant Flagellum Heterotaxy Proteomics identification

外部链接

UniProt: Q8N1V2

NCBI Gene

GeneCards