神经酰胺激酶样蛋白
神经酰胺激酶样蛋白
Q49MI3功能描述
未检测到神经酰胺激酶活性。CERKL的过表达在氧化应激条件下保护细胞免于凋亡。 {ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}.
组织特异性
Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver.
亚细胞定位
Cytoplasm. Nucleus, nucleolus. Note=Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum.
关键词