CEP162 Q5TB80

162 kDa中心体蛋白 (Cep162) (QN1同源蛋白)

功能描述

促进初级纤毛过渡区的组装所必需。通过特异性识别并结合轴丝微管发挥作用。在纤毛发生前定位于中心粒末端，并直接结合轴丝微管，从而促进并限制过渡区特异性形成于纤毛基部。介导CEP290与微管的结合所必需。 {ECO:0000269|PubMed:23644468}。

亚细胞定位

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis.