着丝粒蛋白K (CENP-K) (间期着丝粒复合物蛋白37) (蛋白AF-5alpha) (p33)
着丝粒蛋白K (CENP-K) (间期着丝粒复合物蛋白37) (蛋白AF-5alpha) (p33)
Q9BS16功能描述
CENPA-CAD（核小体远端）复合物的组分，该复合物被招募至着丝粒，参与动粒蛋白的组装、有丝分裂进程和染色体分离。可能通过与CENPA-NAC复合物相互作用，参与将新合成的CENPA整合到着丝粒中。与KNL1协同作用，将NDC80复合物招募至外动粒。 {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}。
组织特异性
Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.
亚细胞定位
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
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