CENPF P49454

着丝粒蛋白 F (CENP-F) (AH抗原) (动粒蛋白 CENPF) (Mitosin)

功能描述

为有丝分裂中的动粒功能和染色体分离所必需。为动力蛋白、LIS1、NDE1和NDEL1的动粒定位所必需。通过与STX4和SNAP25的关联，作为回收囊泡与微管网络之间的连接，从而调节质膜的回收。通过在细胞分裂和增殖过程中调节RB蛋白的活性，在发育过程中作为口袋蛋白介导的细胞过程的潜在抑制剂。可能在正常胚胎心肌细胞细胞周期中发挥调节或允许作用，并在促进转化及异常分裂的新生心肌细胞的持续有丝分裂中起作用。与RB的相互作用指导胚胎干细胞向心肌谱系分化。通过其C末端参与DNA合成的调节，进而调节细胞周期进程。具有调节骨骼肌生成以及胚胎发生中细胞分化的潜在作用。参与树突状细胞调节针对衣原体的T细胞免疫。 {ECO:0000269|PubMed:12974617, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657, ECO:0000269|PubMed:7651420}。

亚细胞定位

Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.