CEMIP Q8WUJ3

细胞迁移诱导及透明质酸结合蛋白 (EC 3.2.1.35) (参与透明质酸解聚的透明质酸结合蛋白)

功能描述

通过细胞膜相关网格蛋白包被凹陷内吞途径介导透明质酸(HA)的解聚。结合透明质酸。将高分子量透明质酸水解产生中等大小的产物，该过程可能通过快速囊泡内吞和再循环发生，而无需胞质内积累或在溶酶体中消化。参与皮肤真皮和关节炎滑膜中透明质酸的分解代谢。正向上皮-间质转化(EMT)，从而促进肿瘤细胞生长、侵袭和癌症扩散。与HSPA5/BIP协作，以钙和PKC依赖的方式促进癌细胞迁移。可能参与听觉。 {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}。

组织特异性

Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.

亚细胞定位

Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.