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CDS2 O95674

磷酸胞苷转移酶 2 (EC 2.7.7.41) (CDP-DAG合酶 2) (CDP-DG合酶 2) (CDP-二酰甘油合酶 2) (CDS 2) (CDP-二甘油焦磷酸化酶 2) (CDP-二甘油合酶 2) (CTP:磷酸胞苷转移酶 2)

蛋白质信息 (UniProt)

磷酸胞苷转移酶 2 (EC 2.7.7.41) (CDP-DAG合酶 2) (CDP-DG合酶 2) (CDP-二酰甘油合酶 2) (CDS 2) (CDP-二甘油焦磷酸化酶 2) (CDP-二甘油合酶 2) (CTP:磷酸胞苷转移酶 2)

O95674

功能描述

催化磷脂酸 (PA) 转化为CDP-二酰甘油 (CDP-DAG),这是合成磷脂酰甘油、心磷脂和磷脂酰肌醇的关键中间体 (PubMed:25375833)。对底物PA中sn-1和sn-2位点的酰基链性质具有特异性,首选的酰基链组成为1-硬脂酰-2-花生四烯酰-sn-磷脂酸 (PubMed:25375833)。在调节脂滴的生长和成熟方面发挥重要作用,脂滴是处于脂质和能量稳态中心的储存细胞器 (PubMed:26946540, PubMed:31548309)。 {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.

组织特异性

Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas.

亚细胞定位

Endoplasmic reticulum membrane

关键词

Alternative splicing Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Nucleotidyltransferase Phospholipid biosynthesis Phospholipid metabolism Phosphoprotein Proteomics identification