CDHR5 Q9HBB8

钙粘蛋白相关家族成员5 (Mu-原钙粘蛋白) (粘蛋白和钙粘蛋白样蛋白) (粘蛋白样原钙粘蛋白) (MLPCDH)

功能描述

微绒毛间粘附分子，通过其胞外结构域与相邻微绒毛上的CDHR2形成钙依赖性异嗜性复合物。从而控制上皮细胞顶端膜处微绒毛的排列。通过其胞质结构域，与微绒毛胞质蛋白相互作用，形成微绒毛间粘附复合物/IMAC。该复合物在微绒毛和上皮刷状缘分化中发挥核心作用。 {ECO:0000269|PubMed:24725409}。

组织特异性

Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).

亚细胞定位

Apical cell membrane